NO EVIDENCE FOR SELECTION OF HIV-1 WITH ENHANCED GAG-PROTEASE OR NEF FUNCTION AMONG BREAKTHROUGH INFECTIONS IN THE CAPRISA 004 TENOFOVIR MICROBICIDE TRIAL.

No evidence for selection of HIV-1 with enhanced gag-protease or Nef function among breakthrough infections in the CAPRISA 004 tenofovir microbicide trial.

Use of antiretroviral-based microbicides for HIV-1 prophylaxis could introduce a transmission barrier that inadvertently facilitates the selection of fitter viral variants among incident infections.To investigate this, we assessed the in vitro function of gag-protease and nef sequences from participants who acquired HIV-1 during Gift Box Set the CA

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Long term steroid metabolism balance studies in subjects on cholesterol-free and cholesterol-rich diets: comparison between normal and hypercholesterolemic individuals

Regulation of cholesterol metabolism was investigated in eight hypercholesterolemic and five normal individuals by combined intravenous pulse-labeling with radioactive cholesterol and fecal steroids balance techniques.Mean serum cholesterol concentrations ranged from 168 to 717 mg/dl.Experiments were scheduled in the following sequence: a cholester

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Mind the Gap: What explains the education-related inequality in missed opportunities for vaccination in sub-Saharan Africa? Compositional and structural characteristics

Missed opportunities for vaccination (MOV) is an important barrier hindering full immunisation coverage among eligible children.Though factors responsible for MOV are well documented in literature, little attention has been paid to the role of inequalities.The aim of this study is to examine the association between structural or compositional facto

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